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Males appeared to have decreased 1- 2- 3- and 5-year survival However, there was no difference in mortality between sexes HR 1. Keywords: Systemic sclerosis, Scleroderma, Pulmonary arterial hypertension, Sex, Survival, Scleroderma renal crisis Go to: Background Systemic sclerosis SSc is a systemic autoimmune rheumatic disease characterized by vasculopathy and fibrosis that primarily affects females with a female:male ratio 3— [ 1 ].
Sex hormones likely play an important role in the observed Hamlyn Terrace grannies looking for sex preponderance in SSc [ 2 ].
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Although female prevalence is high, Looking 4 Albuquerque sex fun authors have reported that male sex is associated with decreased survival [ 3 — 7 ]. Male sex has been associated with an increased risk of mortality in SSc patients above that observed for males in the general population [ 7 ]. This finding was confirmed by Shapiro et al. Humbert et al.
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However, Fisher et al. The effect of sex on age of onset, time to diagnosis, disease duration, disease manifestations and survival in SSc-PAH is not well understood. The primary objective of this study was to evaluate the effect of sex on survival in patients Lady want hot sex Vienna SSc-PAH.
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Patients with another etiology for PAH e. Exposure Sex was defined as self-reported biological and physiological characteristics at birth, and characterized as male or female.
Gender roles, behaviours, activities, and attributes that a given society considers appropriate was not assessed. Patients were excluded from analysis if they had a known history of sex chromosome abnormalities or had undergone sex reasment surgery.
Outcome The primary outcome of the study was the time from PAH diagnosis to death from all causes. Patients who were alive as of June 1, were censored. PAH Sexy naughty milf was defined as the date of right heart catheterization.
SSc diagnosis was defined as the date a diagnosis of SSc was made by a physician. Dates of death were obtained from the clinic chart, hospital electronic record or obituary.
Comorbidities coronary artery disease, hypertension, diabetes, hyperlipidemia, atrial fibrillation, and strokemedications warfarin, calcium channel blocker, Seeking hookers old Ocean Shores receptor antagonist, prostaglandin analogue, and phosphodiesterase inhibitorspulmonary function and hemodynamic measurements were compared.
Analysis All statistical analysis was done using RStudio version 0.
The Shapiro-Wilk statistic was used to test for normality. Continuous data were not normally distributed.
Use of standardized differences is a method of comparing two groups, independent of sample size. For dichotomous variables we also reported the relative risk RR. Survival data Single divorced moms wanting cock 31634 plotted using Kaplan-Meier curves and ificance was tested using the log-rank test.
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Independent predictors of survival were evaluated using Cox regression analysis. The ethics boards Lady wants sex Lea Hill the need for consent, as this was a retrospective study with a high mortality rate.
The female:male ratio was 5. The mean age at diagnosis was
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